CHARACTERIZATION AND STANDARDIZATION OF MERCURY BASED CHENDURAM USING MODERN ANALYTICAL INSTRUMENTS.
KRISHNAVENI.M1.)VENTHAMARAISELVI.J.P2.,PREMA.S.3ARUNSUDHA4i CHANDRA.T.S.5
' Reader, Government Siddha Medical College,Chennail06. ' Assistant Medical officer, A.A.G.H.I.M., Chennai-106 3 Professor, Tamil University, Tanjore.4 Research Scholar, Department of Biotechnology, IIT, Chennai 5Professor, Department of Biotechnology, IIT, Chennai mail: krishna.veni99@yahoo.com
Siddha system has developed a rich and unique treasure of drug knowledge in which use of metals and minerals is very much advocated. The metal is not used as it is, but after several alchemical operations like calcinations, sublimation converts minerals and metals into a form that is made bio- available to the body. The output of such a process is a fine powder, called chenduram. Though chenduram preparations are widely used in Siddha practically nothing is known as to what happens to the metal when it is subjected to purification and the subsequent process. The traditional texts also do not throw any light on the changes undergone by a metal during the above processes. Chendurams are known to be effective in very small doses, usually a few milligrams. Modern physico- biochemical analytical technologies for analyzing the composition of drugs can help answer the above questions. In this present study Mercury based Gowrichinthamanichenduram was prepared by using 1000 cow dung cakes (AgasthiyarVaidhyaKaaviyam- 1500) and studied for the physico chemical characterization by using modern analytical instruments such as XRD, XRF.ICP-OES and Edax and the sample was screened to determine the LD50.
STANDARDISATION OF NISA AMALAKI TABLETS -AN AYURVEDIC PRODUCT
Dr. S. Jayakumari*, Mrs.Vilayalakhi, Dr.S.Hemalatha, Mrs.Malarkodivelraj, Dr.V.Ravichandran
*author for correspondence. E-mail: nisajayaa@yahoo.com
J
Nisaamalaki tablet an Ayurveda formulation containing turmeric and amla in equal proportion (1:1) is being sold in the market as an antidiabetic drug. It is commercially used. So it was taken up for suggesting a method for standardization of the tablet. A comparative study was made between the fresh sample, prepared sample and marketed sample of raw materials and the identify of the market sample (tablet prepared) was confirmed by pharmacognostic studies, which includes macroscopy, microscopy, quantitative microscopy, powder microscopy and fluorescence analysis. Physicochemical standards also covered out such as ash value, extractive value, loss on drying for individual drug and also the tablet. All the above parameter conforming the identity and purity of the sample (tablet). The individual phytoconstituents of ingredients of tablet was determined by Phytochemical evaluation such as extraction, Phytochemical test for identification, phytochemicaly active extracts of aqueous extracts of amla, alcoholic extract of curcuma, tablet and standards were tested for hypoglycemic activity in normal testing animals (rabbit). Based on pharmacological effect, the active extracts of curcuma and amla were screened for chromatographic analysis for presence of bioactive substance and compared with the extracts of tablet with that of standards. Based on the above, the content of bioactive compounds in individual drug as well as formulated drug have been estimated and form a protocol for the standardization of nisaamalaki tablet.
XRD, SEM AND ELEMENTAL ANALYSIS OF RAW THALAGAM AND PURIFIED THALAGAM
G.LOGESWARI Dr.S.TAMILSELVi S.SAKTHIKALA A.ROSHINI PROF.VICTOR G.RAJAMANICKAM
Siddhars , an anciant scientist have used thalagam for treating chronic diseases. Siddhars never used raw marketed Thalagam as such. The Thalagam was subjected to process of purification called "suddhi". Thalagasuddhi was done by using venpoosanikaaicharu(juice of cucumber maxima), karchunnathelineer (lime water) .equal quantity of nallennai(Gingelly oil). The above processed and purified Thalagam and raw Thalagam is submitted to XRD,SEM and elemental analysis. The results reveal the presence of volatile elements along with Arsenic.
FUTURE PLAN - SIDDHA DRUGS
Dr. R. KAROLIN DAISY RANI, M.D.(S) Dr. M. PITCHAIAH KUMAR, M.D.(S)
Asst. Lecturers, G.S.M.C, Chennai -106.
STANDARDISATION
The process of evaluating the quality and purity of crude drugs by means of various parameters like morphological, microscopical, physical, chemical and biological observation is called "Standardisation".
Need of Standardisation:
To assess the quality of the raw material. To estimate the amount of the active principle present. To achieve batch to batch consistency of finished product. Cost effectiveness. Reproducibility.
Role in identification of botanical same:
Microscopy: Size, Shape, etc.
Microscopy: type & shapes of crystals, starch, trichomes etc.,
(a) Determination of stomatal index.
(b) Determination of Palisade Ratio.
(c) Determination of Vein Islet Number.
Quality evaluation of crude drugs originating from different localities. Suitable time of the harvest. Post harvesting process.
Standardisation of single drug and compound formulation.
WHO Guidelines for Quality Standardised Herbal formulation: Botanical Parameters.
Physico - Chemical Parameters.Pharmacological Parameters.Taxicological Parameters. Will be discussed in this paper
Key Words: Definition of standardization, need of standardization, role in identification of botanical source, microscopic and microscopic characters of crude durgs, WHO Guidelines for Quality Standardised Herbal formulation.
A STANDARDISATION APPROACH IN SIDDHA FOR INTERNAL MEDICINES
* LAKSHMANAKUMAR.V, ** MURUGESAN.M, * JAYASEELAN.K
*PG scholar.Dept of Nanjunoolummaruthuvaneethinoolum, National Institute of Siddha, Chennai - 47. **Prof.&Head, Dept of Nanjunoolummaruthuvaneethinoolum, National Institute of Siddha, Chennai - 47. Eventhough many modern parameters are employed for the quality control of herbomineral preparations, it is not necessary to adopt that techniques for our preparations. This manual deals with the standardization parameters of formulary methods for the well finished internal therapeutic drugs, which is already narrated in our classical Siddha literatures. Now, we are in need to explore our classical standardization parameters by dealing through the properties, characters, identities of the well finished formulary methods such as karkam, chooranam, parpam, chenduram, karuppu, pathangam, mathirai, thylam, nei, kattu etc.
COMPARATIVE STUDY OF DIFFERENT PURIFIED FORMS OF THURUSU
SM. KIRUBHAKARAN *, K. GOWSHIHAN*, Mo. NIRAIMATHI \ Prof.Dr. VICTOR RAJAMANICKAM
*Final BSMS Students - Sri Sai Ram Siddha Medical College And Research Centre,
Sai Leo Nagar, West Tambaram.
As per the literature of Siddha medicine, it is explicit that a major section is focused on metals and minerals. Of these, almost all siddhars have given importance for thurusu - a toxic material. For a single metal or mineral different types of purification method has been said by our siddhars, inorder to eliminate the toxicity present in thurusu, four different forms of purification procedures are adopted. Changes in the four different forms of purification are demonstrated through SEM, elemental analysis, XRD techniques.
A SINGLE CASE STUDY ON KARUPPAI SATHAI KATTIGAL (FIBROID UTERUS)
C.PONMUTHU RANI* H.MUBARAK* G.MASILAMANI**
Siddha Regional Research Institute, Puducherry -13 * Senior Research Fellow (S), E-mail: mubarak.dr@gmail.com. ** Assistant Director i/c, SRRI, Puducherry.
Karuppaivippuruthi (Karuppaisathaikattigal) has been described by the sage Yugi in his VaidyaChinthamani. It may be compared with Fibroid uterus as its symptoms are relevant to the available literature. Fibroids are also called as Myomas, Leiomyomas and Fibromas. Its pathology begins when cells overgrow in the muscular wall of the uterus.
Once a fibroid starts, its growth seems to be linked with the hormone Estrogen. The hormone Progesterone may also promote fibroid growth. Most of the women with fibroids do not have symptoms. This present paper deals about a single case study carried out at Siddha Regional Research Institute, Puducherry for a period of three months. This study has been carried out to assess the efficacy of the coded Siddha drug. The result after treatment reveals the clinical efficacy and safety of the Siddha drug. The clinical parameters, investigations taken before and after treatment and literature citations will be discussed. Keywords: KaruppaiSathaiKattigal, Fibroid
BENEFICIAL EFFECTS OF CRUDE LIQUORICE (ATHIMATHURAM) POWDER
H.MUBARAK* V. N. MARYGOLD SHYAMALA** G.MASILAMANI***
Siddha Regional Research Institute, Puducherry -13 "Senior Research Fellow (S), E-mail: mubarak.dr@gmail.com. "Research Officer ***Assistant Director i/c
Usage of herbal sources for diseases is time-immemorial. But it is not true that all the herbal sources are safe. Most of the plants when given in an extract form give contradictory findings when compared to their traditional usage. Also there are wrong claims over their original properties. The stolon and roots of Glycyrrhizaglabra L (Athimathuram) finds its place in Siddha system of Medicine in the treatment of Peptic Ulcer, for a longer period. But it has been used in Indian pharmacopoeia only a century ahead. It is not given in a crude form but given as the triterpenoid compound Carbenoxolone sodium which is separated from the liquorice glucosideglycyrrhizic acid, is available in the market as DGL. The adverse effect of DGL is retention of Sodium and water with increased excretion of Potassium. The present paper discusses about the clinical and pharmacological studies carried out with Liquorice (Athimathuram) powder, which exhibit the untoward effects of DGL.
Key words: Siddha, Adverse effects, DGL.
CLINICAL EFFECT OF A HYPOGLYCEMIC POLYHERBAL FORMULATION
DIVYA.D*, ISMAIL.A.M.AND SENTHAMARAI.R.
Department of Pharmacy Practice, Periyar College of Pharmaceutical Sciences for Girls.
Tiruchirappalli - 620021.divyatdamodaran@yahoo.com
Diabetes mellitus is a condition in which a person has a high blood sugar (glucose) level as a result of the body either not producing enough insulin, or because body cells do not properly respond to the insulin. Recent scientific investigation has confirmed the efficacy of many herbal preparations. Bioactive plant compounds play a major role in Diabetes treatment. There are several bioactive plants which show hypoglycemic activity with different mechanism of actions. Here an attempt is made to prove the effectiveness of poly-herbal formulation by conventional criteria. The objective of the present investigation is to examine and evaluate the efficacy and organ protective activity of poly- herbal formulation in diabetic patients. The Powders of five different plants, which are known to have hypoglycemic activity, were taken in required quantity and mixed well in the pulverizer and capsulated in 500 mg hard gelatin capsules and administered for four months. The treatment was found to be effective in reducing fasting and postprandial glucose levels to normal levels indicating both short - term and long - term control of glucose metabolism was being achieved with this poly-herbal formulation therapy.
CLINICAL EXPERIENCE ON TREATING HIV PATIENTS WITH SIDDHA DRUG - CLINICAL, SOCIAL AND PSYCHOLOGICAL FEATURES.
DR.S.AYYASAMY & DR. R.SUDHA
Asst. Lecturers, Govt. Siddha Medical College, Chennai-600106 Global trends indicate that patients infected with Human Immune deficiency Virus or full blown cases of Acquired Immune Deficiency Syndrome seek traditional remedies. In India, the State of Tamilnadu initiated studies to understand the efficacy of Siddha drugs in the nineties. With two major centers of virology, one at Christian Medical College and the other at Madras Medical College established laboratories to evaluate the no. of copies of the virus (Viral load) and to estimate CD4 and CD8. A team of Siddha physicians carried out study on RAN (RasagandhiMezhugu, Amukkarachuranam and Nellikaillagam) at Institute of Thoracic Diseases, Tambaram. Yet another landmark development was the evaluation of Siddha drug by the team led by Vaidya. Mandayam Kumar on 'Solar drops' in the injectable form by Siddha Medical Research Institute, Bangalore. This drug was prepared with literature reference from KandarNadiVakkiyam, an unpublished manuscript for which exclusive license was awarded by Director General of Drugs. Govt, of India, probablyfor the first time fora Siddha drug. Later this drug was evaluated by Institute of Thoracic medicine and was also proved to be efficient in the treatment of HIV/ AIDS. Subsequent to this the authors carried out trial of this drug in clinical settings. The current paper deals with the clinical outcome in patients who were evaluated as per ICMR protocol with necessary clinical and laboratory parameters along with social and economic impact on patients.
A PRELIMINARY CLINICAL TRIALS OF NATHAICHOORICHOORANAM IN ATHITHOOLAROGAM - OBESITY DR. J.SHYAMALA, DR.P.PARTHIBAN, DR.ABDUL KADHER.
ganesh.shyamalal0@gmail.comGovt.Siddha medical college .Annahospital, Chennai-106
Obesity - Nowadays it is a globally rising problem leads to the complications like hypertension,diabetes,coronary artery disease.lt is a positive approach to treat the obesity only in herbal origin.to give positive results without any side effects. I assure that the drug NathaichooriChooranam is great boon for as to reduce both the body mass and serum triglyceride levels, further reducing the complications of obesity,which is evolving throughout the world nowadays.
A Preliminary Clinical trials of NathaichooriChooranam in Athithoolarogam - obesity have been done in Govt.Siddha medical college, Annahospital, Chennai-106,along with necessary lab investigations, we can tackle the monster like obesity with the seeds of herbal (Nathaichoori) plant alone. So purely Herbocure for obesity.A Preliminary Clinical trials of NathaichooriChooranam in Athithoolarogam - obesity will be discussed later.
COMBINATION OF SIDDHA DRUGS IN GOUTY ARTHRITIS -ACLINICAL EXPERIENCE
Dr.l.Kumaranandam M.D. (S),
Medical Officer (Siddha), SKM Siddha Ayurveda Clinic, Erode.
Introduction
SKM Siddha Ayurveda Clinic was started in Erode on 1989 by Mr. SKM. Myeilanandhan. Every year about 30,000 people are benefit by our clinic. We are giving treatment by our own GMP certified medicine. Here I would like to share my experience in Gout Arthritis management with Siddha drugs.
Gout
Gout - Disturbed purine metabolism leading to excessive accumulation of uric acid in the blood - an inherited disorder; or impaired excretion of uric acid by the kidneys. The result is accumulation of sodium biurate crystals in some soft tissues. Tissues of predilection are cartilage, tendon, bursa
- Patients, usually beyond 40 yrs of age, are more to get affected.
(i) Arthritis - MP joint of the big toe being a favourite site, onset is acute, pain is severe;
(ii) Bursitis-commonly of the olecranon bursa; or
(iii) Tophi formation deposit of uric acid salt in the soft-tissue.
Total No of Pt Discontinue Continue All are Age group All are
3 1 2
Male 31-53 yrs Non Vegetarian
Normal Value of Serum Uric Acid 3-7 mg/100ml
SeendhilChooranam, ChukkuChooranam, Parangipattai Tablet, RasagandhiMezhugu, MayanaThailam are used in Gout Arthritis with in 2 months period the Serum Uric Acid level become normal. The same time all the signs & symptoms relieved. In future we can make a good combination for Gouty Arthritis by an open trial with this drugs.
- Confirmation of diagnosis - high serum uric acid levels.
Combination of Drugs
SeendhilChooranam 30 gm, ChukkuChooranam 30 gm - take 2 gms powder make it decoction and take twice daily after food. Parangipattai - 2 tablet after food with water. RasagandhiMezhugu -1 Cap After noon with Butter Milk, MayanaThylam 30 ml - External use.
Clinical Trial conducted at SKM Siddha &Ayurvedha Clinic, Erode.
THE EFFECT OF ENNAIKKATTU ON THANDAGA VATHAM
* R.S. Ramaswamy **V. Mahalakshmi
"Professor & Head, Department of SirappuMaruthuvam, National Institute of Siddha. ** Lecturer, Department of SirappuMaruthuvam, National Institute of Siddha, Chennai
Thandagavatham is a kind of rheumatism characterized by severe pain in which the body is rendered like a log of wood, unable to stretch the limbs and pass urine and stools. The body assumes a type of thorough rigidity. The similar symptoms are also found in lumbar spondylosis. Hence, Thandagavatham, according to Yugi muni and T.V. Sambasivampillai, can oe clinically correlated to lumbar spondylosis. This paper deals elaborately with the aetiology, pathology, clinical features and complications of Thandagavatham and the effect of Siddha treatment, especially the external treatment technique 'Ennaikkattu' the mechanism of action of this technique and the benefits etc., The encouraging results of a pilot clinical study of TV with Ennaikkattu, undertaken at our NIS hospital have been explained.
APPLICATION OF THOKKANAM FOR THE MANAGEMENT OF "KUMBA VATHAM" - A CLINICAL STUDY
* DR. A. YAHASUNDARAM MD(S) ** DR. R.S. RAMASWAMY MD(S) *** DR. N.J. MUTHUKUMAR MD(S)
*P.G. Scholar - Final Year M.D(S), Dept. of SirappuMaruthuvam "Professor & Head, Dept. of SirappuMaruthuvam ""Lecturer, Dept. of SirappuMaruthuvam
Thokkanam is one of the unique treatment techniques of Siddha system of medicine used for treating various Neuro-Musculo-Skeletal disorders. Its types and methods are explained in siddha literatures especially in TheranTharu and PatharthaGunaChinthamani. While performing Thokkanam, varma points are also stimulated. The therapeutic effectiveness of thokkanam for the management of Kumbavatham is presented in this paper. Kumbavatham is one of the Vatha diseases mentioned in YugiVaithya Chindamani-800. The clinical features of this disease are mainly pain in the shoulder and upper arm with restriction of movements of the shoulder joint. Patients feel severe pain while rolling in bed and at the time of wearing shirt. The patients are unable to bring their arm to back. Kumbavatham may be correlated to the diseases affecting shoulder joint such as Periarthritis, (Frozen shoulder/Adhesive capsulitis) It is most commonly predominant among diabetics and people with history of trauma.
Type of study : Pilot study
Study centre : Department of SirappuMaruthuvam, National Institute of Siddha, Chennai-47.
In this pilot clinical study, VathaKesariThylam was used for external application for the Thokkanam therapy (Therapeutic massage therapy) for 14 days. No Internal medicines were given during the study period. This study shows marked clinical improvement in the signs and symptoms of the disease and the patients felt considerable relief.
CLINICAL AND PHARMACOLOGICAL STUDIES OF MALAIVEMBATHY THYLAM AND KARPAKIRANTHA THYLAM IN FEMALE INFERTILITY.
DR. M. BIRUNDA DEVI.., MD(S),Lecturer
Sairam Siddha Medical College and Research Center, W.Tambaram,Chennai 44
A clinical study on PENMALADU(female infertility) with the trial drugs, malaivembathythylam and karpakiranthithylam as internal medicines. The pharmacological analysis of both the drugs possess significant Antispasmodic, antihelminthic, ovulatory effect, uterine tonic hormonal correctiveness and clinical results will be discussed in the full paper
KRISHNAVENI.M1.)VENTHAMARAISELVI.J.P2.,PREMA.S.3ARUNSUDHA4i CHANDRA.T.S.5
' Reader, Government Siddha Medical College,Chennail06. ' Assistant Medical officer, A.A.G.H.I.M., Chennai-106 3 Professor, Tamil University, Tanjore.4 Research Scholar, Department of Biotechnology, IIT, Chennai 5Professor, Department of Biotechnology, IIT, Chennai mail: krishna.veni99@yahoo.com
Siddha system has developed a rich and unique treasure of drug knowledge in which use of metals and minerals is very much advocated. The metal is not used as it is, but after several alchemical operations like calcinations, sublimation converts minerals and metals into a form that is made bio- available to the body. The output of such a process is a fine powder, called chenduram. Though chenduram preparations are widely used in Siddha practically nothing is known as to what happens to the metal when it is subjected to purification and the subsequent process. The traditional texts also do not throw any light on the changes undergone by a metal during the above processes. Chendurams are known to be effective in very small doses, usually a few milligrams. Modern physico- biochemical analytical technologies for analyzing the composition of drugs can help answer the above questions. In this present study Mercury based Gowrichinthamanichenduram was prepared by using 1000 cow dung cakes (AgasthiyarVaidhyaKaaviyam- 1500) and studied for the physico chemical characterization by using modern analytical instruments such as XRD, XRF.ICP-OES and Edax and the sample was screened to determine the LD50.
STANDARDISATION OF NISA AMALAKI TABLETS -AN AYURVEDIC PRODUCT
Dr. S. Jayakumari*, Mrs.Vilayalakhi, Dr.S.Hemalatha, Mrs.Malarkodivelraj, Dr.V.Ravichandran
*author for correspondence. E-mail: nisajayaa@yahoo.com
J
Nisaamalaki tablet an Ayurveda formulation containing turmeric and amla in equal proportion (1:1) is being sold in the market as an antidiabetic drug. It is commercially used. So it was taken up for suggesting a method for standardization of the tablet. A comparative study was made between the fresh sample, prepared sample and marketed sample of raw materials and the identify of the market sample (tablet prepared) was confirmed by pharmacognostic studies, which includes macroscopy, microscopy, quantitative microscopy, powder microscopy and fluorescence analysis. Physicochemical standards also covered out such as ash value, extractive value, loss on drying for individual drug and also the tablet. All the above parameter conforming the identity and purity of the sample (tablet). The individual phytoconstituents of ingredients of tablet was determined by Phytochemical evaluation such as extraction, Phytochemical test for identification, phytochemicaly active extracts of aqueous extracts of amla, alcoholic extract of curcuma, tablet and standards were tested for hypoglycemic activity in normal testing animals (rabbit). Based on pharmacological effect, the active extracts of curcuma and amla were screened for chromatographic analysis for presence of bioactive substance and compared with the extracts of tablet with that of standards. Based on the above, the content of bioactive compounds in individual drug as well as formulated drug have been estimated and form a protocol for the standardization of nisaamalaki tablet.
XRD, SEM AND ELEMENTAL ANALYSIS OF RAW THALAGAM AND PURIFIED THALAGAM
G.LOGESWARI Dr.S.TAMILSELVi S.SAKTHIKALA A.ROSHINI PROF.VICTOR G.RAJAMANICKAM
Siddhars , an anciant scientist have used thalagam for treating chronic diseases. Siddhars never used raw marketed Thalagam as such. The Thalagam was subjected to process of purification called "suddhi". Thalagasuddhi was done by using venpoosanikaaicharu(juice of cucumber maxima), karchunnathelineer (lime water) .equal quantity of nallennai(Gingelly oil). The above processed and purified Thalagam and raw Thalagam is submitted to XRD,SEM and elemental analysis. The results reveal the presence of volatile elements along with Arsenic.
FUTURE PLAN - SIDDHA DRUGS
Dr. R. KAROLIN DAISY RANI, M.D.(S) Dr. M. PITCHAIAH KUMAR, M.D.(S)
Asst. Lecturers, G.S.M.C, Chennai -106.
STANDARDISATION
The process of evaluating the quality and purity of crude drugs by means of various parameters like morphological, microscopical, physical, chemical and biological observation is called "Standardisation".
Need of Standardisation:
To assess the quality of the raw material. To estimate the amount of the active principle present. To achieve batch to batch consistency of finished product. Cost effectiveness. Reproducibility.
Role in identification of botanical same:
Microscopy: Size, Shape, etc.
Microscopy: type & shapes of crystals, starch, trichomes etc.,
(a) Determination of stomatal index.
(b) Determination of Palisade Ratio.
(c) Determination of Vein Islet Number.
Quality evaluation of crude drugs originating from different localities. Suitable time of the harvest. Post harvesting process.
Standardisation of single drug and compound formulation.
WHO Guidelines for Quality Standardised Herbal formulation: Botanical Parameters.
Physico - Chemical Parameters.Pharmacological Parameters.Taxicological Parameters. Will be discussed in this paper
Key Words: Definition of standardization, need of standardization, role in identification of botanical source, microscopic and microscopic characters of crude durgs, WHO Guidelines for Quality Standardised Herbal formulation.
A STANDARDISATION APPROACH IN SIDDHA FOR INTERNAL MEDICINES
* LAKSHMANAKUMAR.V, ** MURUGESAN.M, * JAYASEELAN.K
*PG scholar.Dept of Nanjunoolummaruthuvaneethinoolum, National Institute of Siddha, Chennai - 47. **Prof.&Head, Dept of Nanjunoolummaruthuvaneethinoolum, National Institute of Siddha, Chennai - 47. Eventhough many modern parameters are employed for the quality control of herbomineral preparations, it is not necessary to adopt that techniques for our preparations. This manual deals with the standardization parameters of formulary methods for the well finished internal therapeutic drugs, which is already narrated in our classical Siddha literatures. Now, we are in need to explore our classical standardization parameters by dealing through the properties, characters, identities of the well finished formulary methods such as karkam, chooranam, parpam, chenduram, karuppu, pathangam, mathirai, thylam, nei, kattu etc.
COMPARATIVE STUDY OF DIFFERENT PURIFIED FORMS OF THURUSU
SM. KIRUBHAKARAN *, K. GOWSHIHAN*, Mo. NIRAIMATHI \ Prof.Dr. VICTOR RAJAMANICKAM
*Final BSMS Students - Sri Sai Ram Siddha Medical College And Research Centre,
Sai Leo Nagar, West Tambaram.
As per the literature of Siddha medicine, it is explicit that a major section is focused on metals and minerals. Of these, almost all siddhars have given importance for thurusu - a toxic material. For a single metal or mineral different types of purification method has been said by our siddhars, inorder to eliminate the toxicity present in thurusu, four different forms of purification procedures are adopted. Changes in the four different forms of purification are demonstrated through SEM, elemental analysis, XRD techniques.
A SINGLE CASE STUDY ON KARUPPAI SATHAI KATTIGAL (FIBROID UTERUS)
C.PONMUTHU RANI* H.MUBARAK* G.MASILAMANI**
Siddha Regional Research Institute, Puducherry -13 * Senior Research Fellow (S), E-mail: mubarak.dr@gmail.com. ** Assistant Director i/c, SRRI, Puducherry.
Karuppaivippuruthi (Karuppaisathaikattigal) has been described by the sage Yugi in his VaidyaChinthamani. It may be compared with Fibroid uterus as its symptoms are relevant to the available literature. Fibroids are also called as Myomas, Leiomyomas and Fibromas. Its pathology begins when cells overgrow in the muscular wall of the uterus.
Once a fibroid starts, its growth seems to be linked with the hormone Estrogen. The hormone Progesterone may also promote fibroid growth. Most of the women with fibroids do not have symptoms. This present paper deals about a single case study carried out at Siddha Regional Research Institute, Puducherry for a period of three months. This study has been carried out to assess the efficacy of the coded Siddha drug. The result after treatment reveals the clinical efficacy and safety of the Siddha drug. The clinical parameters, investigations taken before and after treatment and literature citations will be discussed. Keywords: KaruppaiSathaiKattigal, Fibroid
BENEFICIAL EFFECTS OF CRUDE LIQUORICE (ATHIMATHURAM) POWDER
H.MUBARAK* V. N. MARYGOLD SHYAMALA** G.MASILAMANI***
Siddha Regional Research Institute, Puducherry -13 "Senior Research Fellow (S), E-mail: mubarak.dr@gmail.com. "Research Officer ***Assistant Director i/c
Usage of herbal sources for diseases is time-immemorial. But it is not true that all the herbal sources are safe. Most of the plants when given in an extract form give contradictory findings when compared to their traditional usage. Also there are wrong claims over their original properties. The stolon and roots of Glycyrrhizaglabra L (Athimathuram) finds its place in Siddha system of Medicine in the treatment of Peptic Ulcer, for a longer period. But it has been used in Indian pharmacopoeia only a century ahead. It is not given in a crude form but given as the triterpenoid compound Carbenoxolone sodium which is separated from the liquorice glucosideglycyrrhizic acid, is available in the market as DGL. The adverse effect of DGL is retention of Sodium and water with increased excretion of Potassium. The present paper discusses about the clinical and pharmacological studies carried out with Liquorice (Athimathuram) powder, which exhibit the untoward effects of DGL.
Key words: Siddha, Adverse effects, DGL.
CLINICAL EFFECT OF A HYPOGLYCEMIC POLYHERBAL FORMULATION
DIVYA.D*, ISMAIL.A.M.AND SENTHAMARAI.R.
Department of Pharmacy Practice, Periyar College of Pharmaceutical Sciences for Girls.
Tiruchirappalli - 620021.divyatdamodaran@yahoo.com
Diabetes mellitus is a condition in which a person has a high blood sugar (glucose) level as a result of the body either not producing enough insulin, or because body cells do not properly respond to the insulin. Recent scientific investigation has confirmed the efficacy of many herbal preparations. Bioactive plant compounds play a major role in Diabetes treatment. There are several bioactive plants which show hypoglycemic activity with different mechanism of actions. Here an attempt is made to prove the effectiveness of poly-herbal formulation by conventional criteria. The objective of the present investigation is to examine and evaluate the efficacy and organ protective activity of poly- herbal formulation in diabetic patients. The Powders of five different plants, which are known to have hypoglycemic activity, were taken in required quantity and mixed well in the pulverizer and capsulated in 500 mg hard gelatin capsules and administered for four months. The treatment was found to be effective in reducing fasting and postprandial glucose levels to normal levels indicating both short - term and long - term control of glucose metabolism was being achieved with this poly-herbal formulation therapy.
CLINICAL EXPERIENCE ON TREATING HIV PATIENTS WITH SIDDHA DRUG - CLINICAL, SOCIAL AND PSYCHOLOGICAL FEATURES.
DR.S.AYYASAMY & DR. R.SUDHA
Asst. Lecturers, Govt. Siddha Medical College, Chennai-600106 Global trends indicate that patients infected with Human Immune deficiency Virus or full blown cases of Acquired Immune Deficiency Syndrome seek traditional remedies. In India, the State of Tamilnadu initiated studies to understand the efficacy of Siddha drugs in the nineties. With two major centers of virology, one at Christian Medical College and the other at Madras Medical College established laboratories to evaluate the no. of copies of the virus (Viral load) and to estimate CD4 and CD8. A team of Siddha physicians carried out study on RAN (RasagandhiMezhugu, Amukkarachuranam and Nellikaillagam) at Institute of Thoracic Diseases, Tambaram. Yet another landmark development was the evaluation of Siddha drug by the team led by Vaidya. Mandayam Kumar on 'Solar drops' in the injectable form by Siddha Medical Research Institute, Bangalore. This drug was prepared with literature reference from KandarNadiVakkiyam, an unpublished manuscript for which exclusive license was awarded by Director General of Drugs. Govt, of India, probablyfor the first time fora Siddha drug. Later this drug was evaluated by Institute of Thoracic medicine and was also proved to be efficient in the treatment of HIV/ AIDS. Subsequent to this the authors carried out trial of this drug in clinical settings. The current paper deals with the clinical outcome in patients who were evaluated as per ICMR protocol with necessary clinical and laboratory parameters along with social and economic impact on patients.
A PRELIMINARY CLINICAL TRIALS OF NATHAICHOORICHOORANAM IN ATHITHOOLAROGAM - OBESITY DR. J.SHYAMALA, DR.P.PARTHIBAN, DR.ABDUL KADHER.
ganesh.shyamalal0@gmail.comGovt.Siddha medical college .Annahospital, Chennai-106
Obesity - Nowadays it is a globally rising problem leads to the complications like hypertension,diabetes,coronary artery disease.lt is a positive approach to treat the obesity only in herbal origin.to give positive results without any side effects. I assure that the drug NathaichooriChooranam is great boon for as to reduce both the body mass and serum triglyceride levels, further reducing the complications of obesity,which is evolving throughout the world nowadays.
A Preliminary Clinical trials of NathaichooriChooranam in Athithoolarogam - obesity have been done in Govt.Siddha medical college, Annahospital, Chennai-106,along with necessary lab investigations, we can tackle the monster like obesity with the seeds of herbal (Nathaichoori) plant alone. So purely Herbocure for obesity.A Preliminary Clinical trials of NathaichooriChooranam in Athithoolarogam - obesity will be discussed later.
COMBINATION OF SIDDHA DRUGS IN GOUTY ARTHRITIS -ACLINICAL EXPERIENCE
Dr.l.Kumaranandam M.D. (S),
Medical Officer (Siddha), SKM Siddha Ayurveda Clinic, Erode.
Introduction
SKM Siddha Ayurveda Clinic was started in Erode on 1989 by Mr. SKM. Myeilanandhan. Every year about 30,000 people are benefit by our clinic. We are giving treatment by our own GMP certified medicine. Here I would like to share my experience in Gout Arthritis management with Siddha drugs.
Gout
Gout - Disturbed purine metabolism leading to excessive accumulation of uric acid in the blood - an inherited disorder; or impaired excretion of uric acid by the kidneys. The result is accumulation of sodium biurate crystals in some soft tissues. Tissues of predilection are cartilage, tendon, bursa
- Patients, usually beyond 40 yrs of age, are more to get affected.
(i) Arthritis - MP joint of the big toe being a favourite site, onset is acute, pain is severe;
(ii) Bursitis-commonly of the olecranon bursa; or
(iii) Tophi formation deposit of uric acid salt in the soft-tissue.
Total No of Pt Discontinue Continue All are Age group All are
3 1 2
Male 31-53 yrs Non Vegetarian
Normal Value of Serum Uric Acid 3-7 mg/100ml
SeendhilChooranam, ChukkuChooranam, Parangipattai Tablet, RasagandhiMezhugu, MayanaThailam are used in Gout Arthritis with in 2 months period the Serum Uric Acid level become normal. The same time all the signs & symptoms relieved. In future we can make a good combination for Gouty Arthritis by an open trial with this drugs.
- Confirmation of diagnosis - high serum uric acid levels.
Combination of Drugs
SeendhilChooranam 30 gm, ChukkuChooranam 30 gm - take 2 gms powder make it decoction and take twice daily after food. Parangipattai - 2 tablet after food with water. RasagandhiMezhugu -1 Cap After noon with Butter Milk, MayanaThylam 30 ml - External use.
Clinical Trial conducted at SKM Siddha &Ayurvedha Clinic, Erode.
THE EFFECT OF ENNAIKKATTU ON THANDAGA VATHAM
* R.S. Ramaswamy **V. Mahalakshmi
"Professor & Head, Department of SirappuMaruthuvam, National Institute of Siddha. ** Lecturer, Department of SirappuMaruthuvam, National Institute of Siddha, Chennai
Thandagavatham is a kind of rheumatism characterized by severe pain in which the body is rendered like a log of wood, unable to stretch the limbs and pass urine and stools. The body assumes a type of thorough rigidity. The similar symptoms are also found in lumbar spondylosis. Hence, Thandagavatham, according to Yugi muni and T.V. Sambasivampillai, can oe clinically correlated to lumbar spondylosis. This paper deals elaborately with the aetiology, pathology, clinical features and complications of Thandagavatham and the effect of Siddha treatment, especially the external treatment technique 'Ennaikkattu' the mechanism of action of this technique and the benefits etc., The encouraging results of a pilot clinical study of TV with Ennaikkattu, undertaken at our NIS hospital have been explained.
APPLICATION OF THOKKANAM FOR THE MANAGEMENT OF "KUMBA VATHAM" - A CLINICAL STUDY
* DR. A. YAHASUNDARAM MD(S) ** DR. R.S. RAMASWAMY MD(S) *** DR. N.J. MUTHUKUMAR MD(S)
*P.G. Scholar - Final Year M.D(S), Dept. of SirappuMaruthuvam "Professor & Head, Dept. of SirappuMaruthuvam ""Lecturer, Dept. of SirappuMaruthuvam
Thokkanam is one of the unique treatment techniques of Siddha system of medicine used for treating various Neuro-Musculo-Skeletal disorders. Its types and methods are explained in siddha literatures especially in TheranTharu and PatharthaGunaChinthamani. While performing Thokkanam, varma points are also stimulated. The therapeutic effectiveness of thokkanam for the management of Kumbavatham is presented in this paper. Kumbavatham is one of the Vatha diseases mentioned in YugiVaithya Chindamani-800. The clinical features of this disease are mainly pain in the shoulder and upper arm with restriction of movements of the shoulder joint. Patients feel severe pain while rolling in bed and at the time of wearing shirt. The patients are unable to bring their arm to back. Kumbavatham may be correlated to the diseases affecting shoulder joint such as Periarthritis, (Frozen shoulder/Adhesive capsulitis) It is most commonly predominant among diabetics and people with history of trauma.
Type of study : Pilot study
Study centre : Department of SirappuMaruthuvam, National Institute of Siddha, Chennai-47.
In this pilot clinical study, VathaKesariThylam was used for external application for the Thokkanam therapy (Therapeutic massage therapy) for 14 days. No Internal medicines were given during the study period. This study shows marked clinical improvement in the signs and symptoms of the disease and the patients felt considerable relief.
CLINICAL AND PHARMACOLOGICAL STUDIES OF MALAIVEMBATHY THYLAM AND KARPAKIRANTHA THYLAM IN FEMALE INFERTILITY.
DR. M. BIRUNDA DEVI.., MD(S),Lecturer
Sairam Siddha Medical College and Research Center, W.Tambaram,Chennai 44
A clinical study on PENMALADU(female infertility) with the trial drugs, malaivembathythylam and karpakiranthithylam as internal medicines. The pharmacological analysis of both the drugs possess significant Antispasmodic, antihelminthic, ovulatory effect, uterine tonic hormonal correctiveness and clinical results will be discussed in the full paper
1 comment:
nice blogspot.. update more post... we are vegetarian caterers catering services in chennai and caterers in tambaram , anna nagar chennai .
Post a Comment